Fri Sep 23 2022

74 articles - From Friday Sep 16 2022 to Friday Sep 23 2022

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Guidelines

Guidelines, position statements, white papers, technical reviews, consensus statements, etc…

Ann Intern Med

The Management of Major Depressive Disorder: Synopsis of the 2022 U.S. Department of Veterans Affairs and U.S. Department of Defense Clinical Practice Guideline.

Select recommendations that were identified by the authors to represent key changes from the prior CPG are presented in this synopsis. The scope of the CPG is diverse; however, this synopsis focuses on key recommendations that the authors identified as important new evidence and changes to prior recommendations on pharmacologic management, pharmacogenomics, psychotherapy, complementary and alternative therapies, and the use of telemedicine.

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Meta-analysis

meta-analyses and systematic reviews

Lancet

The clinical effect of point-of-care HIV diagnosis in infants: a systematic review and meta-analysis.

In HIV-exposed infants, same-day point-of-care HIV testing was associated with significantly improved time to result delivery, time to antiretroviral therapy initiation, and proportion of HIV-positive infants starting antiretroviral therapy within 60 days compared with standard of care. Funding The Bill & Melinda Gates Foundation.

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Original articles

RCT, clinical trials, retrospective studies, etc…

Ann Intern Med

Effectiveness of an Unsupervised Online Yoga Program on Pain and Function in People With Knee Osteoarthritis : A Randomized Clinical Trial.

Compared with online education, an unsupervised online yoga program improved physical function but not knee pain at 12 weeks in people with knee osteoarthritis, although the improvement did not reach the MCID and was not sustained at 24 weeks. National Health and Medical Research Council and Centres of Research Excellence.

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Patient-Reported Outcomes Measures in Cardiovascular Disease: An Evidence Map of the Psychometric Properties of Health Status Instruments.

Given the use of PROMs to guide FDA approvals of drugs and devices in CVDs, there is a need for better adherence to quality standards in PROM validation. None.

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Lancet

Combined nivolumab and ipilimumab with or without stereotactic body radiation therapy for advanced Merkel cell carcinoma: a randomised, open label, phase 2 trial.

The combination of nivolumab and ipilimumab represents a new first-line and salvage therapeutic option for advanced Merkel cell carcinoma. Funding Bristol Myers Squibb Rare Population Malignancy Program.

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Dupilumab in children aged 6 months to younger than 6 years with uncontrolled atopic dermatitis: a randomised, double-blind, placebo-controlled, phase 3 trial.

Dupilumab was well tolerated and showed an acceptable safety profile, similar to results in older children and adults. Funding Sanofi and Regeneron Pharmaceuticals.

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Linzagolix with and without hormonal add-back therapy for the treatment of symptomatic uterine fibroids: two randomised, placebo-controlled, phase 3 trials.

Partial suppression with once-per-day linzagolix (100 mg) without add-back therapy potentially provides a unique option for the chronic treatment of symptomatic uterine fibroids in women who cannot or do not want to take concomitant hormonal add-back therapy. Funding ObsEva.

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Long-term outcomes after catheter-based renal artery denervation for resistant hypertension: final follow-up of the randomised SYMPLICITY HTN-3 Trial.

From 12 months to 36 months after the procedure, patients who were originally randomly assigned to receive renal artery denervation had larger reductions in blood pressure and better blood pressure control compared with patients who received sham control. Funding Medtronic.

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N Engl J Med

A Bivalent Omicron-Containing Booster Vaccine against Covid-19.

The bivalent omicron-containing vaccine mRNA-1273.214 elicited neutralizing antibody responses against omicron that were superior to those with mRNA-1273, without evident safety concerns. (Funded by Moderna; ClinicalTrials.gov number, NCT04927065.).

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Cerebral Embolic Protection during Transcatheter Aortic-Valve Replacement.

Among patients with aortic stenosis undergoing transfemoral TAVR, the use of CEP did not have a significant effect on the incidence of periprocedural stroke, but on the basis of the 95% confidence interval around this outcome, the results may not rule out a benefit of CEP during TAVR. (Funded by Boston Scientific; PROTECTED TAVR ClinicalTrials.gov number, NCT04149535.).

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Glycemia Reduction in Type 2 Diabetes - Glycemic Outcomes.

All four medications, when added to metformin, decreased glycated hemoglobin levels. However, glargine and liraglutide were significantly, albeit modestly, more effective in achieving and maintaining target glycated hemoglobin levels. (Funded by the National Institute of Diabetes and Digestive and Kidney Diseases and others; GRADE ClinicalTrials.gov number, NCT01794143.).

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Glycemia Reduction in Type 2 Diabetes - Microvascular and Cardiovascular Outcomes.

In participants with type 2 diabetes, the incidences of microvascular complications and death were not materially different among the four treatment groups. The findings indicated possible differences among the groups in the incidence of any cardiovascular disease. (Funded by the National Institute of Diabetes and Digestive and Kidney Diseases and others; GRADE ClinicalTrials.gov number, NCT01794143.).

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Trial of Antisense Oligonucleotide Tofersen for SOD1 ALS.

(Funded by Biogen; VALOR and OLE ClinicalTrials. gov numbers, NCT02623699 and NCT03070119; EudraCT numbers, 2015-004098-33 and 2016-003225-41.).

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Lancet

Amyotrophic lateral sclerosis.

Although most recent advances have yet to translate into patient benefit, the idea of amyotrophic lateral sclerosis as a complex syndrome is already having tangible effects in the clinic. This Seminar will outline these insights and discuss the status of the management of amyotrophic lateral sclerosis for the general neurologist, along with future prospects that could improve care and outcomes for patients with amyotrophic lateral sclerosis.

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Circadian rhythms and disorders of the timing of sleep.

Very few high-quality epidemiological and intervention studies exist, and wider recognition and treatment of sleep timing disorders are currently hindered by a scarcity of accessible and objective tools for quantifying sleep and circadian physiology and environmental variables. We therefore assess emerging wearable technology, transcriptomics, and mathematical modelling approaches that promise to accelerate the integration of our knowledge in sleep and circadian science into improved human health.

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COVID-19: the case for prosociality.

Pubmed   Journal   ReadQx   PMC

Offline: Swearing allegiance to change.

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The Lancet Commission on lessons for the future from the COVID-19 pandemic.

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Understanding and approaching excessive daytime sleepiness.

Furthermore, EDS can have implications for health as it is thought to act as a risk factor for other conditions, such as cardiovascular and neurodegenerative disorders. Because of the heterogeneous causes of EDS and the complexity of its pathophysiology, management will largely depend on the cause, with the final aim of making treatment specific to the individual using precision medicine and personalised medicine.

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Waking up to the importance of sleep.

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N Engl J Med

After Metformin - Next Steps for Type 2 Diabetes with Low Cardiovascular Risk.

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Audio Interview: Can Vaccines Prevent Transmission of Covid-19?

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Burkitt's Lymphoma.

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Does Capturing Debris during TAVR Prevent Strokes?

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Miscellaneous

misc publications eg case reports, tools of the trade, images of the month, etc…

Ann Intern Med

Annals Consult Guys - Standardizing Venous Thromboembolism Prophylaxis in the Setting of Orthopedic Surgery.

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Annals for Educators - September 2022.

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Annals for Hospitalists - September 2022.

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Annals for Hospitalists Inpatient Notes - Clinical Pearls-Updates on Clostridioides difficile Infection for Hospitalists.

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Annals On Call - Professionalism.

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Cell Front: The House Calls of Mass Incarceration.

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Effectiveness of Motivational Interviewing in Managing Overweight and Obesity.

Pubmed   Journal   ReadQx 

Effectiveness of Motivational Interviewing in Managing Overweight and Obesity.

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Effectiveness of Motivational Interviewing in Managing Overweight and Obesity.

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Making Arrangements.

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Prayer Flags.

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Preconception Antidiabetic Drugs in Men and Birth Defects in Offspring.

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Preconception Antidiabetic Drugs in Men and Birth Defects in Offspring.

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Summary for Patients: Effectiveness of an Online Yoga Program on Pain and Function in Participants With Knee Osteoarthritis.

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The Dodo.

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The Worth of a Life.

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Lancet

A sweet unilateral pleural effusion: pleuro-peritoneal communication in a patient on dialysis.

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Biological therapy for young children with atopic dermatitis.

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Chile abolishes copayments in step towards UHC.

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Combined nivolumab and ipilimumab in non-resectable Merkel cell carcinoma.

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COPD in Colombia.

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Linzagolix: an oral gonadotropin-releasing hormone receptor antagonist treatment for uterine fibroid-associated heavy menstrual bleeding.

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Point-of-care HIV diagnosis for infants: the outcomes we need to achieve.

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SYMPLICITY HTN-3: failure at 6 months, success at 3 years?

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The impact of war on the environment and health: implications for readiness, response, and recovery in Ukraine.

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N Engl J Med

Case 29-2022: A 33-Year-Old Man with Chronic Diarrhea and Autoimmune Enteropathy.

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Jackstone Calculus in the Bladder.

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Pushing Back with Pills - Enhancing Access to Reproductive Health Drugs after Dobbs.

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The Law of Licensure and Quality Regulation.

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The On- and Off-Ramps of Oncology Accelerated Approval.

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The Seeds of Ignorance - Consequences of a Booming Betel-Nut Economy.

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Transforming Management of Opioid Use Disorder with Universal Treatment.

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Wellens' Syndrome.

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Letters&Replies

Letters to the editors and authors’ replies

Lancet

A call for more evidence documenting human-to-dog transmission of monkeypox virus.

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The addition of pelvic lymph node treatment to prostate bed salvage radiotherapy - Authors' reply.

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The addition of pelvic lymph node treatment to prostate bed salvage radiotherapy.

Pubmed   Journal   ReadQx 

The addition of pelvic lymph node treatment to prostate bed salvage radiotherapy.

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The addition of pelvic lymph node treatment to prostate bed salvage radiotherapy.

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The future of Iran's health workforce.

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N Engl J Med

Anti-Spike Mucosal IgA Protection against SARS-CoV-2 Omicron Infection.

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Efficacy of Antiviral Agents against the Omicron Subvariant BA.2.75.

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IL-1RA Antibodies in Myocarditis after SARS-CoV-2 Vaccination.

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Trastuzumab Deruxtecan in HER2-Low Breast Cancer.

Pubmed   Journal   ReadQx 

Trastuzumab Deruxtecan in HER2-Low Breast Cancer.

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Trastuzumab Deruxtecan in HER2-Low Breast Cancer. Reply.

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Treatment of Mantle-Cell Lymphoma.

Pubmed   Journal   ReadQx 

Treatment of Mantle-Cell Lymphoma.

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Treatment of Mantle-Cell Lymphoma.

Pubmed   Journal   ReadQx 

Treatment of Mantle-Cell Lymphoma. Reply.

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Vaccine-Induced Immune Thrombocytopenia and Thrombosis after the Sputnik V Vaccine.

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